Amanda Knox and her former Italian boyfriend Raffaele Sollecito have been found guilty at their retrial for the murder of British student Meredith Kercher in 2007.
The court sentenced Knox to 28 years and six months in prison while Sollecito was sentenced to 25 years.
Knox, who now lives in Seattle, pleaded not guilty in her third trial before the Italian Supreme Court.
The verdict, which took nearly 12 hours of deliberation, overturned the pair’s successful 2011 appeal after four years in jail.
The guilty verdict was read out in a courtroom in Florence, where Meredith’s brother Lyle and sister Stephanie were present.
The court ordered that damages be paid by the pair to Meredith’s family.
Prosecutors claim Meredith was the victim of a drug-fuelled sex game gone wrong after she was found with her throat slashed in the bedroom of the house she shared with Knox.
Throughout all three trials, Knox and Sollecito have pleaded their innocence.