Wearing a black J’Aton gown, Keddie won the Logie award for most popular actress and outstanding actress.
In her acceptance speech for outstanding actress, the 39-year-old praised the other nominees, including her Offspring co-star Kat Stewart.
“I feel so honoured to a part of this group of women,” she said.
“I watch you all, I love you all. You inspire me.”
Keddie, who plays Nina Proudman in the hit television show, dedicated the award to the late Wendy Hughes. “I aspired to have her incredible wit, her beautiful poise, strength and vulnerability and I toast her tonight,” she said.
The fifth series of Offspring starts on May 14.