The New York Police Department confirmed to People that a camera, laptop and some of the 67-year-old’s jewellery was stolen.
The star was out of town, but her son Miles Robbins, 22, was, although he reportedly left the home between the hours of 8 p.m. and 9 p.m.
When he returned in the early hours of Sunday morning, he realised that someone had been in the house and called police, People reported.
Sarandon joins a long list of celebrities who have been targeted by thieves. Orlando Bloom had $500,000 of jewellery taken from his Hollywood Hills home in 2009.